Peculiarities of post-viral chronic fatigue syndrome associated with mild cognitive decline in patients with atypical chronic active herpesvirus infections

According to modern ideas, changes in the functioning of immune system affect processes nervous system, contributing development neuro-immuno-inflammation and thereby indirectly rate progression neurodegenerative processes. The aim our study was investigate prevalence post-viral chronic fatigue syndrome cognitive impairment (aMCI) among patients with atypical, active herpesvirus infections (ACA-HVI). Under supervision were 126 both sexes aged 18 60 years ACA-HVI. It established that mono-EBV infection affects 27.7%; mixed EBV is observed 72.3% patients. When assessing using CGI, MMSE scales, incidence aMCI found be 68.3%: HVI — 87.4%, mono 38.8%. During study, significant limitations identified use standard scales due impossibility conducting a comprehensive assessment clinical status parameters dysfunctions, as well correlation these dynamics immunocorrection. To achieve this goal Scale criterion symptoms ACA-HVI CFS used. shown mixed-HVI, severity exceeded mono-HVI 52.7 (43.1-62.2) 38.0 (31.9-42.8) points, respectively (p > 0.05). Thus, it suffering from have more pronounced, severe manifestations aMCI, which are 1.5 times higher than similar mono-HVI, significantly reducing quality life patients, worsening their social adaptation. Prolonged persistence herpes viruses immune-compromised people creates conditions for constant antigenic stimulation imbalance onset secondary immunodeficiency or manifestation existing primary disorders prerequisites neuro-immuno-inflammatory followed by formation ME/CFS different impairments may classified aMCI.